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Results Methylcobalamin is a specific and direct inhibitor of GSDME Our previous research found that bile acids as DAMPs can directly engage to trigger pyroptotic cell death of hepatocytes 16,19

Latchoumycandane et al., 2007

Consistent with previous studies (Zhang and Cui 2022

doi: 10.1111/imm.12765 112 MariettaEMangalamAKTanejaVMurrayJA

This inflammatory process happens at 3 levels as follows: acute stage (the first hours of incidence of stroke), in which microglia damage the degenerated cells and leukocytes infiltrate, commonly neutrophils