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Cell 235 LuY.IandievI.HollbornM.KorberN.UlbrichtE.HirrlingerP.et al (2011)

Chan DA, Sutphin PD, Yen S-E, Giaccia AJ (2005) Coordinate regulation of the oxygen-dependent degradation domains of hypoxia-inducible factor 1

In these experiments, the thermal denaturation of the proteins is followed by monitoring the fluorescence enhancement of a probe (SYPRO Orange) that binds to protein hydrophobic patches upon denaturation process in the presence or absence of chemical compounds

Altogether, this study highlights the great impact of PO as an important early risk factor in shaping obesity-related metabolic impairments during childhood

A notable study by Cattane et al