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Molecular defects in Friedreichs ataxia: convergence of oxidative stress and cytoskeletal abnormalities

Coyle, P., Philcox, J

The modified FXa polypeptides provided herein, which have been modified to exhibit an activity analogous to the zymogen, can be administered at doses comprised between 10-1000 pg / kg, such as between about 10-250 pg / kg and generally between 10 and 75 pg / kg, such as 40 pg / kg (see, for example, published U.S

SSG dynamically balances pro-survival and pro-death signals

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