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Master Antioxidant: It is the catalyst molecule that enables all other antioxidants (such as vitamins C and E) to become active again in the body

[DOI] [PMC free article] [PubMed] [Google Scholar] 73.Donadio J.L.S., Guerra-Shinohara E.M., Rogero M.M., Cozzolino S.M.F

In both cases, there was a significant attenuation of pathology with reduced tau phosphorylation and neuronal loss in MAPTP301S mice, as well as a 70-80% reduction in amyloid-beta (A) and plaque load in APP/PS1 mice

Metformin-activated AMPK also reduces the degradation of intracellular caspase-3 protein by inhibiting the proteasome, inducing apoptosis in tumor cells (77, 78)