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The insulin signaling pathway has been put forward as a possible mechanism underlying the association between obesity and CRC, since increased levels of circulating insulin (as seen with increased fat tissue) stimulate colorectal epithelial cell proliferation in rat models [40]

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Twenty six percent in Gr.A and 31.1% in Gr.B had at least 5% weight loss in 6 months (P=0.59) The median controlled attenuation parameter was 288 (195-400) dB/m in Gr.A and 287 (170-381) dB/m in Gr.B (P=0.42) at baseline