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(2020) observed alterations in the composition of intestinal microbiota (particularly firmicutes and Bacteroidetes ) as well as significant elevations in metabolites associated with the microbiome, including short/medium chain fatty acids, arginine, and tryptophan derivatives, in rats exhibiting cardiac hypertrophy

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Studies suggest that the VEGF/VEGFR-2 pathway may be particularly relevant, as its activation seems to trigger intracellular signaling cascades that potentially influence endothelial cell migration, proliferation, and survival

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