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Another nuclear receptor, peroxisome proliferator-activated receptor (PPAR-), modulates gene expression related to inflammation and mediates antimycobacterial responses against M.tb infection by activating the expression of genes associated with autophagy, lysosomal function, and phagosomal maturation through lipid catabolism and upregulation of TFEB transcription[54]

Animal studies have shown efficacy in reducing lung damage induced by LPS and sepsis resulting from caecal ligation and puncture in murine models