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Signaling pathways documented in literature: Follicle stimulation Ex vivo models of human hair follicles document elongation and proliferation of dermal papilla cells Copper Signaling: The copper (II) complex is associated in literature with extracellular matrix modulation and dermal angiogenesis DOCUMENTED SCIENTIFIC EVIDENCE Pyo HK et al., Biol Pharm Bull 2007 (PMID 17703734): AHK-Cu in in vitro human hair follicle growth and dermal papilla cell proliferation studies Pickart L, Margolina A, Int J Mol Sci 2018 (PMID 30041448): Copper peptide review in dermal remodeling and extracellular matrix Research material only

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doi: 10.1126/science.aao0185 3