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While many patients feel better with B12, its not required for everyone

Berberine side effects are predominantly gastrointestinal and may include: Diarrhoea, constipation, or abdominal discomfort Nausea and flatulence Cramping or bloating These effects are typically dose-dependent and may be minimised by starting with lower doses and taking berberine with meals

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To use the spray, simply insert the nozzle into one nostril, close the other nostril with your finger, and spray the recommended number of pumps while inhaling gently