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Notably, controlled fluid flow introduces sustained perfusion and physiologically relevant shear forces, both of which modulate cellular behaviour and allow for a more accurate assessment of nanoparticle transport, distribution and cellular uptake than static in vitro models [175, 176]

A common approach is 2-3 mL BAC water per 10 mg vial

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Budesonide multimatrix is efficacious for mesalamine-refractory, mild to moderate ulcerative colitis: a Randomised, Placebo-controlled Trial