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Received: Accepted: Published: Version of record: DOI: Comments Very impressive paper

99101 These advancements represent a major step forward in gene editing applications, providing new targeted treatment options for patients with these challenging genetic conditions

Melanosome formation is an important step in melanognesis and melanosomes need to be transferred to keratinocytes from melanocytes for the completion of this step

Studies have demonstrated that -ketoglutarate (-KG) derived from glutaminolysis promotes M2 activation via metabolic and epigenetic reprogramming (262)

Thus in agreement with its role as a soluble, three-dimensional diffusant in the intermembrane space of mitochondria, the cyt c carries electrons from the membrane-bound Complex III to cyt c oxidase (Cortese et al