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Therefore, increasing the proportion of PEs with AA and AdA side chains in the inner layer of the biomembrane is a necessary condition to ensure lipid peroxidation during ferroptosis

The lack of standard diagnostic criteria for HT makes the diagnosis process subjective and does not cover the entire spectrum of the disease

Research shows that in senescent cells, p53 levels are maintained low through ubiquitination while its pro-apoptotic activity is repressed through nuclear segregation by FOXO4. The peptide's competitive inhibition restores p53 activity by promoting nuclear exclusion, allowing p53 to execute its pro-apoptotic program and eliminate senescent cells through targeted pathway activation