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One of the key mechanisms is increased membrane fluidity, which impairs drug penetration and decreases intracellular accumulation, thereby reducing the drugs effectiveness

Additionally, PAs appear to protect against lung damage through the TGF-1/Smad2/3 signaling pathway

In a hypoxic and glucose-deprived TME, The metabolism of Gln is essential for tumor cells to survive and multiply ( Additionally, metabolomic analyses reveal low levels of Gln and elevated levels of glutamate in TNBC, suggesting that TNBC is more dependent on Gln and more sensitive to therapies targeting Gln breakdown compared to other breast cancer subtypes ( The role of Gln is critical in both the proliferation and metastasis of cancer cells

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