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58 Additionally, G6PD activity can be regulated by several signaling pathways in tumors, such as the PI3K/AKT, Ras, Src, Nrf2, mTORC1, PETEN, ATM, and TP53 pathways, in a direct or indirect manner (reviewed in refs

Brugger J, Schick MA, Brock RW, Baumann A, Muellenbach RM, Roewer N, Wunder C: Carbon monoxide has antioxidative properties in the liver involving p38 MAP kinase pathway in a murine model of systemic inflammation

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& Wang, G

The complexity of tumor biology necessitates a comprehensive approach to treatment, and targeting specific proteins like MTH1 could offer a new pathway for effective cancer therapies