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Reducing the intake of red and white meat (Wang et al., 2019), introducing new dietary modalities such as a high-fat ketogenic diet (LCHF) (Lu et al., 2023) and the mediterranean diet ( 4.2 Gut microbiota manipulation The gut microbiota plays a pivotal role in converting dietary components into TMAO, suggesting that modulation of the gut microbiota could serve as a viable approach to regulating TMAO levels

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These measures will ensure regular oversight and timely identification of any issues that may affect the integrity of the trial