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In tolerance assay, at 42 h after the end of conditioning regimen, shorter preconvulsive latencies than in healthy (non-diazepam conditioned) mice following isoniazid (800 mg/kg i.p.) (as hallmark of tolerance) were observed if diazepam (5.0 mg/kg i.p.) was again given acutely to mice previously conditioned with diazepam alone (use of picrotoxin 3.0 mg/kg i.p., as convulsant, with acute application of diazepam in previously diazepam conditioned mice did not lead to tolerance hallmark)

The level of GSH was calculated by subtracting the content of GSSG from the amount of total glutathione (GSSG + GSH)

Crystal structure of NALP3 protein pyrin domain (PYD) and its implications in inflammasome assembly

The increase in the reduced form of glutathione caused a decrease in the amount of GSSG and inversely (Fig