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doi: 10.1080/08039488.2019.1664630 62 JirakranKVasupanrajitATunvirachaisakulCAlmullaAFKuberaMMaesM

10.1021/es2039757 136 MisraS

NMDA receptor activation underlies the loss of spinal dorsal horn neurons and the transition to persistent pain after peripheral nerve injury

For instance, accumulated succinate acts as a competitive inhibitor of -KGdependent dioxygenases, including the ten-eleven translocation (TET) family of DNA demethylases and Jumonji C domain-containing (JMJD) family histone demethylases, thereby promoting global DNA hypermethylation and transcriptional silencing [51]