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Lower expression of EGFR ligands epiregulin and amphiregulin were correlated with less efficacy of cetuximab treatment in mCRC patients (68, 69)

However, a functional assignment of these residues remains difficult because of the absence of structures with transition-state analogues that allow the discrimination between the glutathione moieties from the GSSR substrate or GSH (Fig

Several fungal vaccines have shown efficacy in preclinical studies, with some advancing to early clinical trials

Contrary, aging-related Klotho deficiency was associated with FOXO1 inactivation and downregulation of antioxidant enzymes in aged SAMP8 mice 35

This can often be corrected by surgery or other methods