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Hypoxia and extracellular acidity have direct effects on the activity and/or uptake of some anticancer drugs, independent of proliferative status

Folate must be checked alongside B12, and folate deficiency should never be treated in isolation when B12 is low, because doing so can mask the anaemia while neurological damage progresses

10.1016/j.pain.2006.01.037 159

158,178 SARS-CoV-2 infection results in the accumulation of released mitochondrial DNA, which subsequently activates cGAS, leading to the initiation of IFN-I signaling