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At the moment the bubbles close, a powerful shock wave is produced, creating localized high pressure and temperature surround bubbles

For this to occur, a marker that predicts patient response to the drug is essential

In addition, second-line treatments such as GnRH agonists effectively reduce pain but are compromised by significant menopausal side effects and challenges with long-term tolerability, which has prompted the development of novel oral GnRH antagonists like elagolix, linzagolix, and relugolix that offer dose-dependent estrogen suppression and rapid reversibility

2005;90:F5236

Immunogenicity of therapeutic monoclonal antibodies