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Nel 2022, la FDA ha emesso avvertimenti a diverse aziende che commercializzavano peptidi, incluso il BPC-157, come prodotti terapeutici senza autorizzazione

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[212] [213] However, it's worth noting that excessive Zn intake or exposure can impair immune function, lead to digestive issues, cause color vision deficiency decrease contrast sensitivity and eye irritation, and disrupt the balance of Cu in the body, which is essential for protecting the eyes from sunlight

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Polycythemia vera has also been reported with parenteral methylcobalamin