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However, DFP demonstrated inconsistent efficacy in other neurodegenerative diseases (Pandolfo et al., 2014)

Whether apoE deficiency also impacts the lipid metabolism of the brain is currently a major topic of discussion, but more detailed studies are required to understand the exact mechanism of APOE4 function in neuronal lipid metabolism (Liu et al

216 In a similar approach, Pandey and Kuller demonstrated that SLNs made up of stearic acid may also be used as potential delivery vehicles for INH, RIF, and PZA

Conversely, interventions that have combined IF with exercise have been proved feasible and suggest that participants are able to perform moderate- to high-intensity endurance or resistance exercise during extended periods of fasting (Reference Bhutani, Klempel and Kroeger32,Reference Kotarsky, Johnson and Mahoney67,Reference Moro, Tinsley and Bianco74)

Ethics declarations Declaration of Competing Interest The authors have no conflicts of interest to declare