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doi:10.1017/S0033291716002932 Adeoye O, Olawumi J, Opeyemi A, Christiania O

PMC+1 The presence of copper is critical because it acts as a cofactor for lysyl oxidase and other enzymes necessary for proper collagen cross-linking and stabilization

Similar studies using inactivated whole-virus or viral-vector-based vaccines for SARS-CoV or MERS-CoV resulted in immunopathology following viral challenge 59,60,61 , which were linked to Th2-cytokine-biased responses 55 and/or excessive lung eosinophilic infiltration 57