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In this review, we provide a succinct overview focusing on the regulatory role of succinate in innate immune cells, highlighting involved mechanisms and research gaps that represent promising targets for future study

This Fe 2+ fuels Fenton reactions, generating hydroxyl radicals that initiate acyl-CoA synthetaselong-chain family member 4 (ACSL4) / lysophosphatidylcholine acyltransferase 3(LPCAT3)-dependent lipid peroxidation: ACSL4 activates polyunsaturated fatty acids (PUFAs, e.g., arachidonic acid, AA/ adrenic acid, AdA), and then LPCAT3 incorporates them into membrane phospholipids (phosphatidylethanolamine-arachidonic acid/ adrenic acid, PE-AA/AdA), thus making them susceptible to oxidation by lipoxygenases (ALOXs

86 Vitamin C also activates ten-eleven translocation proteins and inhibits pluripotency, eliminating the epigenetic and metabolomic profile of cancer cells