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& Klaassen, C

Although the successful application of TyU19 and KYV-201 in IMIDs encourages the further exploration of allogeneic CAR-T therapy in patients with severe and refractory IMIDs (120), the optimal timing for allogeneic CAR-T therapy in autoimmunity requires further investigation due to the potential unknown short- and long-term safety risks and toxicity associated with off-the-shelf CAR-T therapies (150152)

In particular, TGF-1 favors EMT by directly activating a series of signaling pathways including Smad, ERK/MAP kinases, and networks involving microRNAs, through the binding with type I and type II TGF receptors (TBR-I and TBR-II)