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Effect of diallyl disulfide and garlic oil on different human astrocytoma cell lines

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10.3390/cells8080828 Summary Keywords sulfide:quinone oxidoreductase (SQOR), hydrogen sulfide (H 2 S), ferroptosis, coenzyme Q10, colorectal cancer, ulcerative colitis, sulfide oxidation pathway, mitochondrial bioenergetics Citation Peng M-H, Zhang K-L, Ma Z-W, Zhang H-W, Guan S-W and Yu H-B (2025) SQOR as a metabolic rheostat of H 2 S: structure, redox homeostasis, and disease therapy

In synovial macrophages, GYY4137 induces p65 persulfidation (particularly at Cys38), preserving mitochondrial membrane potential and suppressing pyroptosis-associated cytokine release (IL-1, IL-18) ( H 2 S further integrates with metabolic pathways to suppress NF-B

L-Alanine was used as the isonitrogenous control