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In addition, for GFI1B patients, bone marrow MKs showed extensive peripheral cytoplasm with irregular proplatelets and were largely devoid of cell organelles,12 while more recent in vitro differentiation assays with mutant GFI1B constructs in stem cells showed abnormal proplatelet formation.40 Further studies are needed to discover if GATA1-GFI1B co-transcriptional complexes could regulate NBEAL2 expression during megakaryopoiesis