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SLCO/OATP-like transport of glutathione in FASL-induced apoptosis: glutathione efflux is coupled to an organic anion exchange and is necessary for the progression of the execution phase of apoptosis

Always consult your rheumatology team

Key dosing points from the study: Dose range: 200500 mcg per session (individual variation based on severity and body weight) Frequency: 23 sessions per week during the active treatment phase Duration: 48 weeks of active treatment Route: Local subcutaneous injection proximal to the affected joint Concurrent therapy: Most patients continued physical therapy alongside BPC-157 treatment The combination of local administration and physical therapy aligns with the hypothesis that BPC-157 accelerates structural repair while functional loading (exercise) guides proper tissue remodeling