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Clin Pharmacol Ther 83:368371 Amacher DE (1998) Serum transaminase elevations as indicators of hepatic injury following the administration of drugs

353 , e2000068 (2020)

Exogenous sources of free radicals include environmental factors such as ultraviolet (UV) radiation, ionizing radiation, tobacco smoke, pollution, and exposure to certain chemicals and drugs [24]

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Methylation Capacity Second, NNMT inhibition affects cellular methylation capacity: SAM is required for hundreds of methyltransferase reactions throughout the cell, and NNMT's consumption of SAM can deplete this critical resource, while the SAH produced by NNMT is a potent product inhibitor of many methyltransferases