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In recreational athletes, supraphysiological GH doses are often used either alone or in combination with other doping substances (140), and studies have shown that GH improves anaerobic sprint capacity, but not strength and endurance (141), and increases GH, IGF-I and fasting insulin levels (142, 143) mimicking those seen in acromegaly patients ( Table 1 )

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Ultrastructural pathology and restoration in PFC and hippocampal CA1 neurons Transmission electron microscopy (TEM) analysis of prefrontal cortex (PFC) and hippocampal CA1 neurons revealed significant ultrastructural alterations across experimental groups