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Resveratrol is a peroxidase-mediated inactivator of COX-1 but not COX-2: a mechanistic approach to the design of COX-1 selective agents

It has been suggested that the accumulation of D-2-hydroxyglutaric acid may contribute to impaired mitochondrial energy metabolism, increased oxidative stress, activation of N-methyl-D-aspartate (NMDA) receptors, and increased glutamate uptake, which may have toxic effects on cells and nerves [54], leading to the occurrence of epilepsy

However, there was no patient who started BCAA supplementation during the study period

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I am one of few that has been affected by these disorders, and this influence has driven me to research them extensively