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This effect is thought to be mediated through GLP-1 receptors in the cardiovascular system and is generally not clinically significant, though patients with certain arrhythmias or those sensitive to heart rate changes should be monitored

Researchers must carefully consider these pharmacokinetic challenges

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In addition, the authors would like to express their gratitude to Rick Lammers (Pharmacist, Gelderse Vallei Hospital, Ede, the Netherlands) for his insightful advice regarding the issue of norepinephrine base and tartrate

While most patients tolerate B12 shots well, mild side effects can occasionally occur, including minor pain or redness at the injection site, mild diarrhoea, or, in rare instances, an allergic reaction