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J Oncol Pharm Pract

Pernicious anaemia is caused by a deficiency in vitamin B12, due to atrophic gastritis, an autoimmune condition (immune system destroys self), in this case the parietal cells of the stomach that produce intrinsic factor, a glycoprotein that binds to vitamin B12 in the stomach and is essential for normal absorption of vitamin B12 in the small intestine into the blood

Meaningful results require concurrent caloric restriction, structured dietary fat intake, and often prescription medication support

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Their structure relies the interplay of local cells and the extracellular matrix (ECM), made up of parallel collagen fibers