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Smith GS, Barrett FS, Joo JH, Nassery N, Savonenko A, Sodums DJ, et al

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Moreover, RSL3 at tumoricidal doses is cytotoxic to normal cells such as neurons (199), fibroblasts (200) and nephrocytes (201) and shows poor selectivity and pharmacokinetics due to covalent binding to GPX4 via a reactive alkyl chloride moiety (202)

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In a single-blinded RCT, the researchers revealed that Tretiome was superior to lycopene as for the refinement of mouth opening and burning sensation ( While the above studies assessed the efficacy of lycopene in comparison to other drugs or their combination for OSF, the study by Subramaniam et al