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Particularly in conditions with increased IR, resistin may promote hepatic fat accumulation and inflammation [214]

The antisense strand of the siRNA is incorporated into the RISC complex, while the sense strand of the siRNA duplex is lost due to helicase activity [108]

While we aimed to minimize confounding factors affecting metabolites, caution is needed when interpreting AA changes in SLE and LN patients, as factors like diet and inflammation may also influence metabolic pathways