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Kangtai and Zhu Ying of the Eastern Wu Dynasty mentioned in their Biography of Fu Nan that In the rising sea, the coral reef falls, and there is a rock at the bottom of the reef, and the coral grows on it ( Newly Revised Materia Medica (659 AD) as sweet, flat, and nontoxic and primarily used for blood retention and corneal opacity

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In addition, Nox4 facilitates cardiac-related adaptation to chronic stress by activating Nrf2, which increases concentrations of GSH and, consequently, increases the GSH/GSSG ratio [158]

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