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Deviation of the observed pathway score from the null distribution was quantified by the fraction of times that the simulated score was more extreme than the observed score

Mol Microbiol 105:413425 Schnupf P, Hofmann J, Norseen J, Glomski IJ, Schwartzstein H, Decatur AL (2006) Regulated translation of Listeriolysin O controls virulence of Listeria monocytogenes

Perhaps, the simultaneous use of therapies founded on lipid peroxidation along with remedies that either inhibit antioxidant mechanisms, or adversely interact with other pathways, may help bypass this problem [283]