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R 3 and R 4 are independently selected from the group consisting of: hydrogen, C1-C12 alkyl, C1-C12 substituted alkyl, C1-C12 alkenyl, C1-C12 substituted alkenyl, C1-C12 alkynyl, and C1-C12 substituted alkynyl, or optionally R 3 and R 4 together are bonded to form a fused bicyclic ring system or a spirocyclic ring system, where the fused ring is a C3-C8 heterocycloalkyl or C 6 - C10 aryl or C4-C10 heteroaryl

Proc Natl Acad Sci USA 114:52895294 Marschner P (2012) Marschners mineral nutrition of higher plants, 3rd edn

Growing evidence indicates that acute or chronic liver injury is strongly associated with gut microorganisms, and the importance of gut-liver interaction has been increasingly emphasized [5]

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Although the primary behavioral outcomes of addictive substances are realized through distinct effector mechanisms, such as neurotransmitter transporters, ion channels, and receptor proteins, the common feature of these drugs is concerned with increased dopamine neurotransmission within the mesocorticolimbic circuitry of the brain from the ventral tegmental area to the nucleus accumbens and prefrontal cortex [1]