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the compositions comprise a cannabinoid (e.g., CBD) and a cofactor or precursor thereof (e.g., niacinamide) at a molar ratio of about 50 : 1, about 49 : 1, about 48 : 1, about 47 : 1, about 46 : 1, about 45 : 1, about 44 : 1, about 43 : 1, about 42 : 1, about 41 : 1, about 40 : 1, about 39 : 1, about 38 : 1, about 37 : 1, about 36 : 1, about 35 : 1, about 34 : 1, about 33 : 1, about 32 : 1, about 31 : 1, about 30 : 1 , about 29 : 1 , about 28 : 1 , about 27 : 1 , about 26 : 1 , about 25 : 1 the compositions comprise a cannabinoid (e.g., CBD) and a mitophagy stimulant (e.g., urolithin A) at a molar ratio of between about 50:1 and about 1:80

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However, the cellular source and precise regulatory mechanism of CCL19 in IgG4-RD remain to be clarified

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