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Primary myelofibrosis: 2023 update on diagnosis, risk-stratification, and management

The expression and activity of ACLY are significantly upregulated in several malignancies such as bladder, breast, lung, liver, stomach, prostate, and colon cancers (12, 1418), and the overexpression of ACLY correlates with poor prognosis in lung adenocarcinoma and blood cancers (15, 19)