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Palbociclib in advanced acral melanoma with genetic aberrations in the cyclin-dependent kinase 4 pathway

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10.1016/j.envexpbot.2018.02.001 74 LiuP

[156] Aside from overloading endogenous CCSdependent and independent metalation pathways, [154] disproportionately high SOD1 expression may create a mismatch between Cu demand and supply in the brain and spinal cord, where Cu import is much less efficient than in the periphery.[ 134 , 157 ] This may contribute to SOD1 mismetalation and partially underlie the reduction in SOD1 specific activity (SOD1 enzymatic activity per unit of protein) observed in transgenic mutant SOD1 mice