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BMSCs-EVs alleviate pelvic floor dysfunction in mice by reducing inflammation and promoting tissue regeneration [J]

These characteristics lead to the poor penetration of chemotherapy (98100) and can cause intra-tumoral hypoxia and an accumulation of acid (95, 101104) which in turn antagonizes anti-tumor immunity by stimulating immune checkpoint expression (105, 106) and immunosuppressive myeloid cells

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It is a gradual process that can start as early as the 20s but is most commonly observed in middle-aged women