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DED is associated with an imbalance in Th17/Treg cells, leading to increased Th17 polarization and secretion of pro-inflammatory cytokines like IL-17, causing epithelial damage (Ratay et al., 2017)

That said, the effects of hypohomocysteinemia would be the prolonged inflammatory insults experienced by the body due to the increased formation of free radicals with the lack of GSH to counteract the effect

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In guinea pigs, the administration of curcumin and encapsulated DEX prior to treatment effectively mitigated the ototoxic effects of cisplatin, thereby safeguarding auditory function across all frequencies