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A VE map provides a look-up table for functionality of coding variants in disease-associated genes, potentially providing strong evidence that can be collected in advance of the first clinical observation of a patient variant, so that it is immediately available to assist clinical variant interpretation [9, 10], meeting a clinical need that is particularly acute for rare and personal variants found via sequencing

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Figure 1 The second study assessed the capacity of divalproex sodium to reduce the incidence of CPS when administered as the sole AED

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Consequently, the balance between system Xc and glutamate transport is disrupted, leading to both a reduced intracellular uptake of glutamate and an inhibition of GSH synthesis due to the lack of necessary raw materials (87)