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Chronic inflammation in the brain triggers immune activation and the release of pro-inflammatory agents, impairing the clearance of neurotoxic substances or directly harming neurons [81]

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Down-regulated peroxisome proliferator-activated receptor (PPAR) in lung epithelial cells promotes a PPAR agonist-reversible proinflammatory phenotype in chronic obstructive pulmonary disease (COPD)

The stringent factor RelA adopts an open conformation on the ribosome to stimulate ppGpp synthesis

and Jain, RK