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NIK level is also elevated in pancreatic islets of diet-induced obese mice in a mechanism involving NIK pathway activation by RANK ligand (RANKL) [137]

It has earlier been reported that the NF-B p65 subunit inhibits the Nrf2/ARE pathway at the transcriptional level (Liu et al., 2008), so there may be crosstalk between NF-B and Nrf2 in the decrease of Nrf2 expression

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This progress forms a fundamental basis for the development of innovative therapeutic interventions targeting GIRK channels