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Clinicians utilizing these findings have developed targeted treatment protocols, often referred to as the "Brewer Protocol," which focus on eradicating fungal colonization in the sinus cavities using biofilm disruptors and intranasal antifungals

Translocation of HpaA-AvrBs32 and HpaA 1-70 -AvrBs32 was significantly reduced in strain 85* hpaC when compared with strain 85*, suggesting that the N-terminal translocation signal targets HpaA for HpaC-dependent translocation (Figure 5D)

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