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T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression

Liu et al., 2011)

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Clinically, veterinary patients who suffer from heat stress have been shown to experience clinical signs that range in severity from mildly decreased feed intake and milk production (reported in dairy cows) to more severe consequences including altered immune responses [55] and death [56,57]