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Hyperammonemia in children: on the crossroad of different disorders

Administration of the resveratrol-rich supplement (resveratrol: 8 mg/day for 6 months, then 16 mg/day for another 6 months) significantly improved the profile of circulating inflammatory markers, reducing levels of C-reactive protein (CRP) and Tumor Necrosis Factor- (TNF-), as well as the level of thrombogenic factor, Plasminogen Activator Inhibitor-1 (PAI-1) (109)

Moon Kim and Woong-Sup Lee of Seoul National University for providing the technical support to present study

Kossoff EH, McGrogan JR, Bluml RM, Pillas DJ, Rubenstein JE, Vining EP

However, when in excess, as is the case in PD-neurons, NO alters axo-dendritic function impairing synaptic signaling, vesicular trafficking, and dopamine homeostasis (Fig