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Although some genes involved in the platelet pathway were upregulated after PPE, they were not altered by necroptosis deficiency, indicating that AAA protection might be primarily mediated through reduced SMC necroptosis and inflammation

& Geiszt M

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In conclusion, though the drugs mentioned above showed good efficacy in preclinical or clinical trials, many tests and a long time would be required to apply to clinical treatment

Gut-derived immune activation exacerbates central pathology in stroke and in autoimmune diseases like MS, while there is evidence that dietary interventions and probiotics can also attenuate disease severity and improve functional outcome